Long-term survival of patients with pulmonary arterial hypertension associated with connective tissue disease: beneficial effects of beraprost sodium, an oral prostacyclin analog
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چکیده
Received 8 December 2016, accepted 26 December 2016 Correspondence to: Sumiaki Tanaka, Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan E-mail: [email protected] Long-term survival of patients with pulmonary arterial hypertension associated with connective tissue disease: beneficial effects of beraprost sodium, an oral prostacyclin analog
منابع مشابه
Long-term survival of Japanese patients with pulmonary arterial hypertension treated with beraprost sodium, an oral prostacyclin analogue.
OBJECTIVE Beraprost was developed as the first oral prostacyclin analog to treat patients with pulmonary arterial hypertension (PAH). Although this drug demonstrates improvements in the patient's exercise capacity and symptoms, it carries a weak recommendation in the PAH evidence-based treatment algorithm due to a lack of durability of effects. However, this therapy remains a major treatment me...
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Pulmonary arterial hypertension (PAH) is commonly associated with CREST (Calcinosis, Raynaud phenomenon, Esophageal motility disorders, Sclerodactyly, and Telangiectasia) syndrome. Sildenafil, an oral phosphodiesterase type-5 inhibitor, may offer benefits in the pharmacological management of PAH. However, little is known about the long-term hemodynamic effects of sildenafil, and the potential r...
متن کاملOrally active prostacyclin analogue in primary pulmonary hypertension.
Primary pulmonary hypertension is a disease of unknown aetiology that is progressive and uniformly fatal. However, substantial improvement in the duration and quality of life has been reported in patients who have received long-term intravenous prostacyclin (PGI2) infusion. But this treatment is more uncomfortable for patients and potentially more hazardous than oral therapy. On the other hand,...
متن کاملCARDIOVASCULAR MEDICINE Oral beraprost sodium improves exercise capacity and ventilatory efficiency in patients with primary or thromboembolic pulmonary hypertension
Objective: To investigate the effect of beraprost sodium, an orally active prostacyclin analogue, on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension and chronic thromboembolic pulmonary hypertension. Patients and design: Symptom limited cardiopulmonary exercise testing was performed before and 3 (1) months (mean (SEM)) after beraprost treatment in 30...
متن کاملOral beraprost sodium improves exercise capacity and ventilatory efficiency in patients with primary or thromboembolic pulmonary hypertension.
OBJECTIVE To investigate the effect of beraprost sodium, an orally active prostacyclin analogue, on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension and chronic thromboembolic pulmonary hypertension. PATIENTS AND DESIGN Symptom limited cardiopulmonary exercise testing was performed before and 3 (1) months (mean (SEM)) after beraprost treatment in 30...
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